80,000+ Skills to Supercharge Claude
The open directory for GitHub-integrated capabilities, tools, and prompts for your AI workflows.
bio-sam-bam-basics
by GPTomics
View, convert, and understand SAM/BAM/CRAM alignment files using samtools and pysam. Use when inspecting alignments, con...
bio-sequence-similarity
by GPTomics
Find homologous sequences using iterative BLAST (PSI-BLAST), profile HMMs (HMMER), and reciprocal best hit analysis. Use...
bio-chipseq-peak-calling
by GPTomics
ChIP-seq peak calling using MACS3 (or MACS2). Call narrow peaks for transcription factors or broad peaks for histone mod...
bio-alignment-pairwise
by GPTomics
Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use for comparing two sequences, finding...
bio-atac-seq-atac-peak-ca...
by GPTomics
Call accessible chromatin regions from ATAC-seq data using MACS3 with ATAC-specific parameters. Use when identifying ope...
bio-pathway-go-enrichment
by GPTomics
Gene Ontology over-representation analysis using clusterProfiler enrichGO. Tests whether GO terms are enriched in a gene...
bio-methylation-calling
by GPTomics
Extract methylation calls from Bismark BAM files using bismark_methylation_extractor. Generates per-cytosine reports for...
bio-workflows-fastq-to-va...
by GPTomics
End-to-end DNA sequencing workflow from FASTQ files to variant calls. Covers QC, alignment with BWA, BAM processing, and...
bio-sequence-statistics
by GPTomics
Calculate sequence statistics (N50, length distribution, GC content, summary reports) using Biopython. Use when analyzin...
bio-variant-annotation
by GPTomics
Comprehensive variant annotation using bcftools annotate/csq, VEP, SnpEff, and ANNOVAR. Add database annotations, predic...
bio-genome-assembly-hifi-...
by GPTomics
High-quality genome assembly from PacBio HiFi reads using hifiasm with phasing support. Use when building reference-qual...
bio-workflows-expression-...
by GPTomics
Workflow from differential expression results to functional enrichment analysis. Covers GO, KEGG, Reactome enrichment wi...
bio-database-access-unipr...
by GPTomics
Access UniProt protein database for sequences, annotations, and functional information. Use when you need protein data,...
bio-copy-number-cnv-annot...
by GPTomics
Annotate CNVs with genes, pathways, and clinical significance. Use to interpret CNV calls and identify affected genes.
bio-proteomics-spectral-l...
by GPTomics
Build, manage, and search spectral libraries for proteomics. Covers DDA-based library generation, predicted libraries (P...
bio-restriction-fragment-...
by GPTomics
Analyze restriction digest fragments using Biopython Bio.Restriction. Predict fragment sizes, get fragment sequences, si...
bio-metagenomics-strain-t...
by GPTomics
Track bacterial strains using MASH, sourmash, fastANI, and inStrain. Compare genomes, detect contamination, and monitor...
bio-chipseq-differential-...
by GPTomics
Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires...
bio-workflows-proteomics-...
by GPTomics
End-to-end proteomics workflow from MaxQuant output to differential protein abundance. Orchestrates data import, normali...
bio-pdb-structure-navigat...
by GPTomics
Navigate protein structure hierarchy using Biopython Bio.PDB SMCRA model. Use for accessing models, chains, residues, an...
bio-data-visualization-ge...
by GPTomics
Create genome browser-style visualizations showing multiple data tracks (coverage, peaks, genes) using pyGenomeTracks, G...
bio-chipseq-visualization
by GPTomics
Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks...
bio-read-alignment-star-a...
by GPTomics
Align RNA-seq reads with STAR (Spliced Transcripts Alignment to a Reference). Use for RNA-seq data requiring splice-awar...
