80,000+ Skills to Supercharge Claude
The open directory for GitHub-integrated capabilities, tools, and prompts for your AI workflows.
bio-phasing-imputation-ha...
by GPTomics
Phase genotypes into haplotypes using Beagle or SHAPEIT. Resolves which alleles are inherited together on each chromosom...
bio-bedgraph-handling
by GPTomics
Create, manipulate, and convert bedGraph files for genome browser visualization. Covers bedGraph format, conversion to/f...
bio-rna-quantification-fe...
by GPTomics
Count reads per gene from aligned BAM files using Subread featureCounts. Use when you have BAM files from STAR/HISAT2 an...
bio-expression-matrix-met...
by GPTomics
Merge sample metadata with count matrices and add gene annotations. Use when preparing data for differential expression...
bio-batch-processing
by GPTomics
Process multiple sequence files in batch using Biopython. Use when working with many files, merging/splitting sequences,...
bio-metagenomics-visualiz...
by GPTomics
Visualize metagenomic profiles using R (phyloseq, microbiome) and Python (matplotlib, seaborn). Create stacked bar plots...
bio-paired-end-fastq
by GPTomics
Handle paired-end FASTQ files (R1/R2) using Biopython. Use when working with Illumina paired reads, synchronizing pairs,...
bio-workflows-spatial-pip...
by GPTomics
End-to-end spatial transcriptomics workflow for Visium/Xenium data. Covers data loading, preprocessing, spatial analysis...
bio-genome-intervals-bigw...
by GPTomics
Create and read bigWig browser tracks for visualizing continuous genomic data. Convert bedGraph to bigWig, extract signa...
bio-single-cell-cell-comm...
by GPTomics
Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor inter...
bio-vcf-manipulation
by GPTomics
Merge, concatenate, sort, intersect, and subset VCF files using bcftools. Use when combining variant files, comparing ca...
bio-crispr-library-design
by GPTomics
CRISPR library design for genetic screens. Covers sgRNA selection, library composition, control design, and oligo orderi...
bio-workflows-multiome-pi...
by GPTomics
End-to-end multiome workflow for joint scRNA-seq + scATAC-seq analysis. Covers data loading, separate modality processin...
bio-proteomics-quantifica...
by GPTomics
Protein quantification from mass spectrometry data including label-free (LFQ, intensity-based), isobaric labeling (TMT,...
bio-flow-cytometry-bead-n...
by GPTomics
Bead-based normalization for CyTOF and high-parameter flow cytometry. Covers EQ bead normalization, signal drift correct...
bio-genome-assembly-assem...
by GPTomics
Assess genome assembly quality using QUAST for contiguity metrics and BUSCO for completeness. Essential for evaluating a...
bio-spatial-transcriptomi...
by GPTomics
Process and analyze tissue images from spatial transcriptomics data using Squidpy. Extract image features, segment cells...
bio-filter-sequences
by GPTomics
Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequence...
bio-genome-assembly-short...
by GPTomics
De novo genome assembly from Illumina short reads using SPAdes. Covers bacterial, fungal, and small eukaryotic genome as...
bio-restriction-enzyme-se...
by GPTomics
Select restriction enzymes by criteria using Biopython Bio.Restriction. Find enzymes that cut once, don't cut, produce s...
bio-metabolomics-normaliz...
by GPTomics
Quality control and normalization for metabolomics data. Covers QC-based correction, batch effect removal, and data tran...
bio-imaging-mass-cytometr...
by GPTomics
Cell type assignment from marker expression in IMC data. Covers manual gating, clustering, and automated classification...
bio-population-genetics-p...
by GPTomics
PLINK file formats, format conversion, and quality control filtering for population genetics. Convert between VCF, BED/B...
bio-hi-c-analysis-matrix-...
by GPTomics
Balance, normalize, and transform Hi-C contact matrices using cooler and cooltools. Apply iterative correction (ICE), co...