80,000+ Skills to Supercharge Claude
The open directory for GitHub-integrated capabilities, tools, and prompts for your AI workflows.
bio-de-edger-basics
by GPTomics
Perform differential expression analysis using edgeR in R/Bioconductor. Use for analyzing RNA-seq count data with the qu...
bio-primer-design-primer-...
by GPTomics
Validate PCR primers for specificity, dimers, hairpins, and secondary structures using primer3-py thermodynamic calculat...
bio-hi-c-analysis-hic-dat...
by GPTomics
Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic form...
bio-sequence-properties
by GPTomics
Calculate sequence properties like GC content, molecular weight, isoelectric point, and GC skew using Biopython. Use whe...
bio-genome-intervals-cove...
by GPTomics
Calculate read depth and coverage across genomic intervals using bedtools genomecov and coverage. Generate bedGraph file...
bio-motif-search
by GPTomics
Find patterns, motifs, and subsequences in biological sequences using Biopython. Use when searching for transcription fa...
bio-spatial-transcriptomi...
by GPTomics
Load spatial transcriptomics data from Visium, Xenium, MERFISH, Slide-seq, and other platforms using Squidpy and Spatial...
bio-basecalling
by GPTomics
Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado or Guppy basecallers. Covers model se...
bio-hi-c-analysis-tad-det...
by GPTomics
Call topologically associating domains (TADs) from Hi-C data using insulation score, HiCExplorer, and other methods. Ide...
bio-metabolomics-lipidomi...
by GPTomics
Specialized lipidomics analysis for lipid identification, quantification, and pathway interpretation. Covers LC-MS lipid...
bio-pdb-structure-modific...
by GPTomics
Modify protein structures using Biopython Bio.PDB. Use for transforming coordinates, removing atoms or residues, adding...
bio-workflows-metabolomic...
by GPTomics
End-to-end metabolomics workflow from raw MS data to pathway analysis. Orchestrates XCMS preprocessing, annotation, norm...
bio-metabolomics-targeted...
by GPTomics
Targeted metabolomics analysis using MRM/SRM with standard curves. Covers absolute quantification, method validation, an...
bio-pdb-structure-io
by GPTomics
Parse and write protein structure files using Biopython Bio.PDB. Use for reading PDB, mmCIF, and MMTF files, downloading...
bio-metabolomics-msdial-p...
by GPTomics
MS-DIAL-based metabolomics preprocessing as alternative to XCMS. Covers peak detection, alignment, annotation, and expor...
bio-metabolomics-metaboli...
by GPTomics
Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence...
bio-proteomics-ptm-analys...
by GPTomics
Post-translational modification analysis including phosphorylation, acetylation, and ubiquitination. Covers site localiz...
bio-crispr-screens-hit-ca...
by GPTomics
Statistical methods for calling hits in CRISPR screens. Covers MAGeCK, BAGEL2, drugZ, and custom approaches for identify...
bio-workflows-cnv-pipelin...
by GPTomics
End-to-end copy number variant detection workflow from BAM files. Covers CNVkit analysis for exome/targeted sequencing w...
bio-imaging-mass-cytometr...
by GPTomics
Spatial analysis of cell neighborhoods and interactions in IMC data. Covers neighbor graphs, spatial statistics, and int...
bio-metabolomics-xcms-pre...
by GPTomics
XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence...
bio-hi-c-analysis-loop-ca...
by GPTomics
Detect chromatin loops and point interactions from Hi-C data using cooltools, chromosight, and HiCCUPS-like methods. Ide...
bio-rnaseq-qc
by GPTomics
RNA-seq specific quality control including rRNA contamination detection, strandedness verification, gene body coverage,...
bio-workflows-cytometry-p...
by GPTomics
End-to-end flow cytometry workflow from FCS files to differential analysis. Orchestrates compensation, transformation, g...